PLoS One. 2012;7(4):e34643. Epub 2012 Apr 11. BACKGROUND: Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the eukaryotic lanthionine synthetase component C-Like protein family involved in signal transduction and insulin sensitization. Recently, LANCL2 is a target for the binding and signaling of abscisic acid (ABA), a plant hormone with anti-diabetic and anti-inflammatory [...]
Accepted by 26th IEEE International Parallel & Distributed Processing Symposium (IPDPS), May 21-25, 2012, Shanghai, China. The article is available as pdf. Here we present the ENteric Immunity Simulator (ENISI), a modeling system for the inflammatory and regulatory immune pathways triggered by microbe-immune cell interactions in the gut. With ENISI, immunologists and infectious disease experts [...]
COmplex PAthway SImulator: A Tool for Modeling Complex Immunological Systems New discoveries in immunology have triggered the production and development of novel, efficient and cost-effective tools to analyze complex immunological networks and target experimental approaches. The goal of the Center for Modeling Immunity for Enteric Pathogens (MIEP) is to support powerful software that can drive [...]
ENteric Immunity SImulator: A Tool for in silico Study of Mucosal Immunity ENISI is a tool for mucosal immunologists to test and generate hypothesized mechanisms for clinical enteric disease outcomes given in vitro observations. ENISI is an agent-based simulator of the antagonistic inflammatory and regulatory immune pathways of the gut as individual immune cells interact [...]
Accepted by IEEE International Conference on Bioinformatics and Biomedicine. The latest version is available in pdf. Clinical symptoms of gastrointestinal (GI) infections are often caused by the inflammatory response elicited to eliminate the invading microbe. Here we present ENISI, a simulator of GI immune mechanisms in response to resident commensal bacteria as well as invading [...]
Accepted to be published in PLoS ONE. The latest version is available in pdf. Background: Treatments for inflammatory bowel disease (IBD) are modestly effective and associated with side effects from prolonged use. As there is no known cure for IBD, alternative therapeutic options are needed. Peroxisome proliferator-activated receptor-gamma (PPARγ) has been identified as a potential [...]
Poster presented at Protein Science, JULY 23-27, 2011, BOSTON, MA. Modulation of the chronic inflammation phenotype associated with many diseases, including diabetes, gastrointestinal diseases, and some cancers, can be attributed to targeting a single family of proteins: peroxisome proliferator-activated receptors (PPAR). With emphasis on PPARgamma, we propose using a time- and cost-effective combined computational and [...]
Abstract presented in IMMUNOLOGY 2011 (AAI) Here we present the newly developed ENteric Immunity SImulator (ENISI) that simulates the antagonistic inflammatory and regulatory immune pathways of the gut as individual immune cells interact with and respond to commensal and foreign bacteria. This tool has been used to reproduce a typical inflammatory response to foreign bacteria [...]
Abstract presented in IMMUNOLOGY 2011 (AAI) H. pylori is a leading cause of peptic ulcer, gastric lymphoma and adenocarcinoma. In spite of being a highly prevalent bacterium in the gastric mucosa, only 15 % of carriers develop overt disease. Bacterial pathogenesis is believed to arise from an interaction of strain-specific immunity-mediating capabilities and the host [...]
Abstract presented in IMMUNOLOGY 2011 (AAI) Mathematical and computational modeling facilitates concurrent multiparametric analyses of dynamic biological processes. Herein we describe a network model illustrating intracellular pathways controlling a naïve T cell differentiation into Th1, Th2, Th17 or iTreg phenotypes. The model is comprised of 37 differential equations representing 40 reactions and 81 species. The [...]
