The following is a structure model of Macrophage developed through CellDesigner. The model is available for download in CellDesigner xml format (right click the link or ctrl+left click for Mac machines to save the model source file). We have tested that the model is compatible with Cell Designer 4.1.

This model has been lastly updated on Jan 11th, 2012. Here is the release note: One species and one reaction were added in the model. The new specie is s140. The reaction is re89. The aim to add these two items is to distinguish different phosphorylations of PPAR gamma. PKA phosphrylates PPAR gamma that increases PPAR gamma activity, while Cdk5 phosphrylates PPAR gamma that decrease PPAR gamma activity.

For previously versions, please go to the archive page.

The primary MIEP Team member responsible for maintaining this model is Pinyi Lu at the Virginia Bioinformatics Institute. Please contact him with any questions or comments.

(Click on the image for a user-friendly interactive CellPublisher model.)