MIEP MissionThe Center for Modeling Immunity to Enteric Pathogens (MIEP) at the Nutritional Immunology and Molecular Medicine Laboratory (NIMML) is a NIAID funded program with the mission of understanding the mechanisms of action underlying immune responses to enteric pathogens.
Upcoming EventsMIEP team to present at Annual Meeting of American Association of Immunologists , Honolulu, Hawaii May 3-7, 2013.
Research HighlightsInvestigators in MIT and Harvard Medical School combined transcriptional profiling at high temporal resolution with high throughput strategies to identify and validate 39 regulatory factors involved in Th17 differentiation
Th17 is a proinflammatory T-cell subset that has been implicated in the pathogenesis of multiple autoimmune and infectious diseases. However, the molecular circuits that control Th17 keep largely unknown. Nir Yosef et al. in the Kuchroo Laboratory identified and validated 39 regulatory factors involved in the induction, expansion, maintenance and suppression of the Th17 phenotype within the CD4+ T cell subset. Yosef et al. embedded those factors in a comprehensive temporal network and they revealed their organizational principles. [more ...]